|
|
|
|
| |
|
|
| Damy,Sueli Blanes; Ebisui,Luci; Spinelli,Marilda Osti; Osaka,Junko Takano; Tolosa,Erasmo Magalhães Castro de; Ortiz,Silvia Colleta Barreto da Costa. |
| Aiming to design a biologic model of acute intra-abdominal sepsis for experimental studies, conventional, isogenic rats F344 were infected with the bacteria Escherichia coli (E.coli), strain 11775, serotype H7:01:K1. Six hours after inoculation with E. coli, the animals - males and females - showed the following symptoms: piloerection, hyperpnea and decreased motor activity. The lethal dosis (LD50), was 6 x 10(5) CFU/ml, analyzed in 32 males and 32 females. The highest mortality rate was observed on the first 24 hours. Liver dysfunction, common in intra-abdominal sepsis, was evaluated at 0, 24, 48 and 168 hours after inoculation, by means of serum enzyme activities. Study of the migration of polymorphonuclear-neutrophil cells (PMN) and... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: SEPSIS Rats Models; Biological. |
| Ano: 2002 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-95962002000100004 |
| |
|
|
| Nascimento,Michele Cardoso do; Abreu,Clarice Lima do Canto; Costa,Rodrigo Netto; Delgado,Wlamir Correa de Moura; Fernandes,Isabella. |
| In this study, we compared the results of potency determination of recombinant human erythropoietin (rhEPO) obtained between 2010 and 2012 by the National Institute of Quality Control in Health (INCQS/Fiocruz), i.e., the National Control Laboratory (NCL), and by a manufacturer of rhEPO. In total, 47 different batches of commercially prepared rhEPO (alpha isoform) were analyzed. All results, including those of the control and warning limits, remained within the limits recommended by European Pharmacopoeia (Ph. Eur.). All relative error (RE) values were less than ± 30%, wh ereas most were approximately ± 20%. Applying the Bland-Altman plot, only two of 47 values remained outside the limits of agreement (LA). In addition, agreement of potency determination... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Recombinant Human Erythropoietin; Biological; Quality Control; Sanitary Surveillance. |
| Ano: 2015 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132015000400562 |
| |
|
|
|
